Endocrine Disorder

I Hyperandrogenism:
-excess production of androgen: adrenal tumor, ovarian tumor
-metabolic derangement: PCOS
-end organ hypersensitivity

Hirsutism; most frequent manifestation
1. Definition
Excessive hair Growth in androgen depedant areas of skin
cf)midline hair: sideburns, moustache, beard,chest or intermammary hair, inner ,midline, lower back(intergluteal area)
2. Hirsutism과 구분해야 하는 것들
-Hypertrichosis: androgen-independant growth of hair(trunk, extremity등 nonsexual area)
-Virilization(남성화):
Regression of female body characteristics and acquisition of male body characteristics
Severe degree of hyperandrogenism, Male pattern temporal balding
Increased muscle mass, Decreased breast size, Clitoromegaly, Coarsening of the voice

3. Role of androgen
① 생성장소: adrenal gland(ACTH),ovary(LH)
② 생성과정: fig. 25.1
③ Principle androgens
- Dihydrotestosterone (DHT)
- Testosterone(T)
- Androstenedione(A`D)
- Dehydroepiandrosteron ( DHEA )
- Dehydro…(생략)