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malignant hepatic tumor 以� 媛��옣 �쓷�븳 寃껋�� metastatic tumor�씠�떎.
1.HCC(hepatocellular carcimoma)
(1)Epidemiology
�쐞�븫,�룓�븫 �벑 �떎瑜� �븙�꽦 醫낆뼇�뿉 鍮꾪빐 �쁽����엳 �궙�쑝�굹 ���媛� 30-40���, �듅�엳 �궓�옄�뿉 �샇諛쒗븯硫�, �썝諛쒖꽦 媛꾩븫�쓽 90%瑜� 李⑥���븯怨� �엳�떎
(2)Etiology
�몺cirrhosis :
HCC �솚�옄�쓽 70% �씠�긽�뿉�꽌 �룞諛섎릺硫� LC �솚�옄�쓽 10-30%�뿉�꽌 HCC媛� �룞諛섎맂�떎. LC瑜� 媛�吏�怨� �엳�뒗 �솚�옄�뿉�꽌 留ㅻ뀈 HCC媛� 諛쒖깮�븷 �쐞�뿕��� 3%�젙�룄�씠�떎.
�몼viral hepatitis :
HBV, HCV�쓽 chronic infection�씠 �썝�씤 以� �븯�굹濡� 瑗쏀엳怨� �엳�떎. 洹멸쾬��� 洹� �옄泥닿�� HCC�쓽 risk factor濡� �옉�슜�븯湲곕룄 �븯吏�留� �씠�윭�븳 virus�쓽 留뚯꽦 媛먯뿼�쑝濡� LC媛� 珥덈옒�릺湲� �븣臾몄씠湲곕룄 �븯�떎. �씠�븣�쓽 LC�뒗 ���泥대줈 macronodular cirrhosis�씠�떎. HBsAg (+)�씤 寃쎌슦 HCC�쓽 鍮덈룄�뒗 HBsAg(-)�씤 寃쎌슦蹂대떎 �빟 100諛� �넂�떎. HBV infection怨� HCC�쓣 媛�吏�怨� �엳�뒗 �솚�옄�뿉�꽌 HBV�쓽 DNA genome��� �씤泥댁쓽 genome�뿉 �궫�엯�릺�뼱 �븫愿��젴 �쑀�쟾�옄瑜� �솢�꽦�솕 �떆�궗 �닔 �엳�쑝硫� 洹� �옄泥닿�� mutagenesis�굹 chromosomal rearrangement瑜� �씪�쑝�궗 �닔�룄 �엳�떎. HCV�뿉 �쓽�븳 hepatitis�룄 non-A, non-B hepatitis�쓽 �쓷�븳 �썝�씤�쑝濡� 瑗쏀엳怨� �엳�쑝硫� �씠�윭�븳 HCV infection �룄 HCC�쓽 risk媛� �맆 �닔 �엳�떎. 洹몃윭�굹 HBV��� HCV�쓽 以묐났媛먯뿼�씠 �씪�뼱�궃 寃쎌슦�쓽 malignancy�쓽 �엫�긽 �뼇�긽��� �씠 virus�뱾�쓽 �븳 醫낅쪟�쓽 媛먯뿼怨� 蹂� 李⑥씠媛� �뾾�떎.
�몾chronic liver disease :
any agent or factor濡� �씤�븳 chronec, low grade liver cell damage�굹 mitosis�룄 genetic alteration�뿉 �쁺�뼢�쓣 誘몄튂誘�濡� �떎�쓬怨� 媛숈�� chronic liv���(�깮�왂)
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Hepatoma.hwp
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