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°æÁ¦¼ºÀå°ú »ê¾÷È­·Î »ýÈ° ¼öÁØÀÌ Çâ»óµÊ¿¡ µû¶ó °Ç°­ ¹× ¹Ì¿ë¿¡ ´ëÇÑ °ü½ÉÀÌ ´õ¿í Ä¿Áö¸é¼­ ºñ¸¸¿¹¹æ ¹× Ä¡·á À§ÇÑ ¿©·¯ °¡Áö ±â´É¼º ½ÄÇ° °³¹ßÀÌ È°¹ßÈ÷ ÀÌ·ç¾îÁö°í ÀÖ´Ù. Conjugated linoleic acid (CLA)´Â ÇʼöÁö¹æ»êÀÎ linoleic acidÀÇ ÀÌÁß°áÇÕÀÇ À§Ä¡ ¹× ±âÇÏÇÐÀû(cis, trans) À̼ºÃ¼¸¦ ÃÑĪÇÏ¿© ºÒ·¯Áö´Â À̸§ÀÌ´Ù. ¿©·¯ À̼ºÃ¼ Áß cis-9, trans-11 ¿Í trans-10, cis-12 À̼ºÃ¼°¡ »ý¸® È°¼ºÀÌ Å« ¹°Áú·Î ¾Ë·ÁÁö°í ÀÖ´Ù(Figure 1). CLA´Â ¹ÝÃßµ¿¹°¿¡¼­ À¯·¡µÈ À°·ù, ¿ìÀ¯ ¹× À¯Á¦Ç°¿¡ Á¸ÀçÇÏ¸ç ±× ÇÔ·®Àº µ¿¹°ÀÇ »çÀ°Á¶°ÇÀ̳ª °¡°øó¸® °úÁ¤¿¡ µû¶ó ´Þ¶óÁø´Ù.

Figure 1. Structure of conjugated linoleic acid

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1.HaY, Grimm NK, Pariza MW. Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis 1987;8:1881-1887.
2.Ip C, Singh M, Thompson HJ, Scimeca JA. Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res 1994;54:1212-1215.
3.HaYL, Storkson J, Pariza MW. Inhibition of benzo[¥á]pyrene- induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res 1990;50:1097-1101.
4.Ip C, Briggs SP, Haegele AD, thompson HJ, Storkson JM, scimeca JA. The efficacy of conjugated linoleic acid in mammary cancer prevention in independent of the level or type of fat in the diet. Carcinogenesis 1996;17: 1045-1050.
5.Ip C, Dong Y, Ip MM, Banni S, Carta G, Angioni E, Murru E, Spada S, Melis MP, Saebo A. Conjugated linoleic acid isomers and mammary cancer prevention. Nutr Cancer 2002;43(1): 52-58.
6.Belury MA. Inhibition of carcinogenesis by conjugated linoleic acid : potential mechanism of action. J Nutr 2002;132:2995-2998.
7.Kim KH. Effect of dietary supplementation of conjugated linoleic aicd on tumor incidence and colon carcinogenesis in 1,2-dimethylhydrazine- treated rats.Ph. D. thesis Kyung Hee University, 2000.
8.Shultz TD, Chew BP, Seaman WR. Differential stimulatory and inhibitory responses of human mcf-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. Anticancer Res 1992;12:2143-2145.
9.Oh YS, Kim EJ , Kim JW, Kim WK, Lee HS, park JHY. The effect of conjugated linoleic acid and its isomers on the proliferation of prostate TSU-Pr1 cancer cells. Korean. J Nutr 2002;35: 192-200.
10.Knekt P, Jarvinen R, Seppanen, R, Pukkala E, Aromma A. Intake of dairy products and the risk of breast cancer. Br J Cancer 1996;73: 687-691.
11.Aro A. Mannisto S, Salminen I, Ovaskainen M L, Kataja V, Uusitupa M. Inverse association between dietary and serum conjugated linoleic acid and risk of breastcancer in postmenopausal women. Nutr Cancer 2000;38: 151-157.
12.Voorrips LE, Brants HAM, Kardinaal AFM, Hiddink GJ, van den Brandt PA, Goldbohm RA. Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. Am J Clin Nutr 2002;76(4): 873-882.
13.Cook ME, Miller CC, Park Y, Pariza ,MW. Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression. Poult Sci 1993;72:1301-1305.
14.Chin SF, Storkson JM, Albright KJ, Cook Me, Pariza MW. Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J Nutr 1994;124 : 2344-2349.
15.Wong MW, Chew BP, Wong TS, Hosick HL, Boylston TD, Shultz TD. Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. Anticancer Res 1997;17:987-993.
16.Yamasaki M, Chujo H, Tachibana H, Yamada K. Immunoglobulin and cytokine production from spleen lympocyte is modulated in C57BL/6J mice by dietary cis-9, trans11 and trans-10, cis-12 conjugated linoleic acid. J Nutr 2003;133(3): 784-788.
17.Same as 7.
18.Yoon KM, Park HS. Conjugated linoleic acid supplemented to dietary fat has an antioxidant activities but it dependent on the type of fat in diet. Korean J Nutr 2001;34(8):858-864.
19.Yurawecz, M.P., Hood, J.K., Mossoba, M.M., Roach,J.A., and Ku,Y. Furan fatty acids determined as oxidation products of conjugated octadecadienoic acid. Lipids 1995;30:595-598.
20.Jeroen JM nan den Berg, Cook NE, Tribble DL. Reinvestigation of the antioxidant properties of conjugated linoleic acid. Lipids 1995;30(7): 599-605.
21.Lee KN, Kritchevsky D, Pariza MW. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 1994;108 : 19-25.
22.Nicolosi RJ, Rogers EJ, kritchevsky D, Scimeca JA, Huth PJ. Dietary conjugated linoleic acid reduce plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery 1997;22(5) : 266-77.
23.Jung SM, Kang KJ, Park HS. Effect of dietary conjugated linoleic acid on plasma lipid composition in rats. Korean J Lipidology 1999;9(4):439-447.
24.Yotsumoto H, Hara E, Naka E, Adlof RO, Emken EA, Yanagita T. 10trans, 12cis-linoleic acid reduces apolipoprotein B secrection in HepG2 cells. Food Res Int 1999;31:403-409.
25.Rudel LL. Atherosclerosis and conjugated linoleic acid. Br J Nutr 1999;81:177-179.
26.Ha,Y.L., Ha,H.S., Ha,J.Kim, Bahn,K.N., Lee,E.J., and Ha,J.K. Effects of dietary conjugated dienoic isomers of linoleic acid (CLA) on cholesterol and CLA contents of hen`s egg. In 1994 IFT Annual Meeting Technical Program: Jun. 25¢¦29, Altant, GA, USA. 79D 6, p249, 1994.
27.Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP Peck LW, Nickel KP, Belury MA. Dietary conjugated linoleic acid normalizes impaires glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Comm 1998;244:678-682.
28.Belury MA, Mahon A, Banni S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr 2003;133(1):257S-260S
29.Riserus U, Arener P, Erismar K, Vessby B. Treatment with dietary trans10 cis12 conjugated linolic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 2002;25(9): 1516-1521.
30.Evans ME, Brown JM, McIntosh MK. Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J Nutr Biochem 2002;13(9):508-516.
31.Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice. Lipids 1997;32: 853-858.
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33.Ostrowska E, Muralitharan M, Cross RF, Bauman DE, Dunshea FR. Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. J Nutr 1999;129: 2037-2042.
34.Yamasaki M, Mansho K, Mishima H,KasaiM, Sugano M, Tachibana H, Yamada K. Dietary effect of conjugated linoleic acid on lipid levels in white adipose tissue of Sprague-Dawley rats. Biosci Biotechnol Biochem 1999;63:1104-1106.
35.Poulos SP, Sisk M, Hausman DB, Azain MJ, Hausman GJ. Pre- and postnatal dietary conjugated linoleic acid alters adipose development, body weight gain and body composition in Sprague-Dawley rats. J Nutr 2001;131:2722-2731.
36.Azain MJ, Hausman DB, Sisk MB, Flatt WP, Jewell DE. Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J Nutr 2000;130:1548-1554.
37.Sisk M, Azain MJ, Hausman DB, Jewell DE. Effect of conjugated linoleic acid on fat pad weights and celluarity in sprague Dawley and Zucker rats. FASEB(abstract) 1999;3116 : A536.
38.Muller H Stangl G, Kirchgessner M. Xnergy balance of conjugated linoleic acid-treated pigs. J Anim Physiol Anim Nutr 1999;81:150-156.
39.Kang KJ. Effects of Conjugated Linoleic Acid Supplementation on Body Fatness and Triglyceride Metabolism in Rats. Ph.D. Thesis. Kyung Hee University 2000.
40.Park YH, Albright KJ, Storkson JM, Liu W, Pariza MW. Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 1999;34 : 235-241.
41.Thom,E. A pilot study with the aim of studying the efficiency and tolerability of Tonalin CLA on the body composition in humans. Medstat Res. Ltd., Oslo, Norway 1997.
42.Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight


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