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I. �젙�쓽
: irreversible, progressive destruction of nephron mass(GFR�넃)
- GFR�넃(3媛쒖썡 �씠�긽)
- uremic Sx(3媛쒖썡 �씠�긽)
- renal osteodystrophy(2` hyperparathyroidism)
- uremic neuropathy
- bilat. small sized kidney(竊�10cm)
- anemia
- metastatic calcification
- broad cast in urinary sediment
II. �썝�씤
: �븳援��뿉�꽌�쓽 �쓷�븳 �썝�씤
1. DM
2. HTN
3. GN
III. 蹂묓깭�깮由�
1) toxin�쓽 泥대궡 異뺤쟻
1. 二쇰줈 �떒諛깆쭏怨� �븘誘몃끂�궛�쓽 ����궗�궛臾쇱씠 異뺤쟻
2. �씠�뱾��� �젙�긽�쟻�쑝濡� �떊�옣�쓣 �넻�빐 諛곗꽕�릺�뒗 臾쇱쭏
3. peptide hormone�뱾�씠 �떊遺��쟾怨� �븿猿� �넁
(�댌�겕寃� �넀�긽�맂 �떊�옣�쓽 �씠�솕�옉�슜怨� 利앷���맂 遺꾨퉬 �븣臾�)
2) cellular function�뿉�쓽 �쁺�뼢
1. cell membrane�쓣 �넻�븳 ion transport�쓽 �옣�븷
�넂 intracellular Na�넁, K�넃 �넂 transcellular electrical potential�넃
2. Na-K-ATPase activity�넃
3) metabolism�뿉�쓽 �쁺�뼢
1. hypothermia
2. CHO metabolism
- �떦����궗 �뒫�젰 �넀�긽 �넂 FBS�뒗 n`l �삉�뒗 �빟媛� �넁
�넂 �댋 CRF�쓽 glucose intolerance�뒗 �듅蹂꾪븳 移섎즺瑜� �븘�슂移� �븡�쓬!
(azotemic pseudodiabetes)
- F���(�깮�왂)
4. nitrogen metabolism
1) K homeostasis
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