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�뿈 �씪諛섏쟻�쑝濡� �쁽�옱 留롮씠 �씠�슜�릺怨� �엳�뒗 �몴�쟻 遺��쐞 : receptor & enzymes(cell envelopes�뿉 議댁옱�븯�뒗)�뿉 �옉�슜, (cell�쓽 envelopes��� microorganisms�쓽 walls, enzymes, receptors, nucleic acids and viruses)
�뿈 洹� �몴�쟻�뿉 ����븳 �쓽�빟�뭹 �씠�뱾�뿉 �옉�슜 湲곗옉 : cell membranes��� walls �뙆愿댁떆�궎嫄곕굹 �씠�뱾�쓽 �삎�꽦�쓣 ����빐, ion channels瑜� blocking �떆�궡. microorganisms�뿉 �옉�슜�븯�뿬 membranes��� walls瑜� 遺뺢눼�떆�궡.
�몺 cell membrane�쓣 �삎�꽦�븯�뒗 �븘�닔 援ъ꽦臾쇰뱾(湲곗쭏, �슚�냼)�쓽 �깮�궛�쓣 ����빐�븿.
�몼 cell wall�쓽 �삎�꽦 怨쇱젙�쓣 ����빐�븿.(以묒슂�븳 cell�쓽 material�쓣 loss�떆�궡�쑝濡쒖뜥 cell wall�쓣 incomplete�븯寃� 留뚮벀.)
�몾 cell wall�씠�굹 membrane�뿉 �옉��� pore(channels)瑜� �삎�꽦�븿.
�몿 �뜑 留롮�� pore瑜� 留뚮벀�쑝濡� �씤�빐 membrane�씠 breaking down�릺�뼱 cell death�맖.
�뿈 Antifungal agent(�빆吏꾧퇏�젣�젣 : �몴 7.1) : fungistatic(洹좊컻�쑁���吏��옉�슜 - �빟�쑝濡� fungus reproducing�쓣 留됱쓣 �븣) & fungicidal(怨고뙜�씠�젣嫄�) action, skin�씠�굹 mucous membrane�뿉 議댁옱.
�몺 Azoles 怨꾪넻��� �뼱�뵒�뿉 �옉�슜(�몴�쟻遺��쐞)�쓣 �븯硫�, �뼱�뼚�븳 �쓽誘몃�� 媛�吏�怨� �엳�뒗媛�?
Azole��� �냽�룄�뿉 �뵲�씪�꽌 洹� 吏꾧퇏�쓣 �궗硫� �떆�궗 �닔�룄 �엳怨�, 利앷퇏 �옉�슜�쓣 �떆�궗 �닔�룄 �엳�떎. �씠寃껊뱾��� fungcidal (micromolar)怨� fungistatic (nanomolar) �솢�꽦�쓣 媛�吏��뒗 1,3-imidazoles �굹 1,2,4-imidazoles �쑀�룄泥대뱾�씠�떎. Cytochrome P-450 enzymes(�뼲�젣)�뒗 寃곌낵�쟻�쑝濡� st���(�깮�왂)
�몼 Allylamine�룄 �뼱�뼚�븳 �몴�쟻�슚�냼�뿉, �뼱�뼚�븳 �쓽�쓽瑜� 媛�吏�怨� �엳�뒗媛�? squalene epoxidase(fungal membrane�뿉 議댁옱)瑜� �뼲�젣�븿. naftifine�쑝濡쒕���꽣 諛쒖깮�맂 3-aminopropene�쓽 �쑀�룄泥�. ex) Naftifine, Terbinafine, Tolnaftate cf) Tolnaftate�뒗 鍮꾨줉 allylamine��� �븘�땲吏�留� 洹몄�� �쑀�궗�븳 �옉�슜.
�몾 Phenols 怨꾪넻�룄 cellular components�쓽 �넀�떎濡� �씤�븳 cell membrane�쓽 �뙆愿대줈 吏꾧퇏�쓣 �뼲�젣�븷 �닔 �엳�뒗 �옉�슜�쓣 �븿. ex) Hexylresorcinol, Chloroxylenol, Cliquinol, Ciclopirox.
�몺 Ionophore(�씠�삩�닾怨쇰떞泥�?)��� �듅�젙�븳 �몴�쟻�쓣 媛�吏�怨� �엳�뒗 寃껋�� �븘�땲怨�, �꽭�룷 �궡��� �꽭�룷 諛뽰쓽 湲덉냽 �씠�삩 �냽�룄瑜� ����벑�븯寃� �쑀吏��븯�뿬二쇰뒗 �듅吏뺤쓣 媛�吏�硫�, 留됱쓣 愿��넻�븷 �닔 �엳怨� �씠�삩�쓽 �궪�닾�꽦�쓣 利앷���떆�궗 �닔 �엳�뒗 臾쇱쭏. 誘몄깮臾쇱뿉�꽌 �븘�닔�쟻�씤 �꽭�룷 援ъ꽦�슂
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